منابع مشابه
Autophagy in adipose tissue.
The possible involvement of the evolutionarily conserved process of autophagy (selfeating) in the pathogenesis of human diseases has been increasingly appreciated in recent years. However, at present, many fundamental questions remain to be answered before autophagy can be considered as a therapeutic target: The biological consequences of activating or inhibiting the process are very much cell ...
متن کاملTranscriptional Dysregulation of Adipose Tissue Autophagy in Obesity.
There is growing interest in understanding how dysregulated autophagy may contribute to pathogenesis of disease. Most frequently, disease states are associated with diminished autophagy, mostly attributed to genetic variation in autophagy genes and/or to dysfunctional posttranscriptional mechanisms. In human adipose tissue (AT), in obesity, expression of autophagy genes is upregulated and autop...
متن کاملFAS and ACC dysfunction in visceral Adipose Tissue
Background and Aim: A great interest for determining the particular mechanisms underlying lipogenesis and adipogenesis has been raised among researchers in order to fight obesity. We aimed to investigate the gene expression of FAS and its role in regulation of lipogenesis and adipogenesis in visceral adipose tissues from obese and normal-weight subjects. materials and Methods: A total of.parti...
متن کاملPTPIP51 in adipose tissue
Protein tyrosine phosphatase interacting protein51 (PTPIP51) interacts both in vit ro and in v ivo withPTP1B, a protein tyrosine phosphatase involved in cellularregulation. PTPIP51 is known to be expressed in manydifferent types of tissues. It is involved in cellular processessuch as proliferation, differentiat ion and apoptosis. Never-theless, the exact cellular functio...
متن کاملImpaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue
Adipose tissue dysfunction in aging is associated with inflammation, metabolic syndrome and other diseases. We propose that impaired protein homeostasis due to compromised lysosomal degradation (micro-autophagy) might promote aberrant ER stress response and inflammation in aging adipose tissue. Using C57BL/6 mouse model, we demonstrate that adipose tissue-derived stromal vascular fraction (SVF)...
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ژورنال
عنوان ژورنال: Obesity Facts
سال: 2012
ISSN: 1662-4033,1662-4025
DOI: 10.1159/000343983